Applied Life Science Infection Revision
- Created by: aimeeporter14
- Created on: 17-10-22 11:42
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- The Process of Infection
- 2. Invasion
- Infectious agent can invade surrounding tissues/other sites.
- Mechanisms are developed to penetrate tissues and avoid hosts nonspecific/specific defences ef immunity and inflammation.
- 4. Spread
- Produce localised infections without spread to other regions of the body.
- Others highly invasive- may enter lymphatics, blood, internal organs.
- Successful spread relies on virulence factors eg adhesion molecules, toxins + protection against host's inflammatory + immune system.
- Fungi are opportunistic!
- If host has an intact immune system, microorganism remain localised.
- If host's immune or inflammatorysystem is compromised then infection may spread rapidly!
- 3. Multiplication
- Warm, nutrient filled host environment.
- Undergo rapid multiplication- replicate within infected cells (viral pathogens).
- Replicate in macrophages+ other cells (bacterial pathogens).
- 1. Colonisation
- The presence of a microorganism in a host without interaction with the organism.
- Infectious microorganisms exist in resevoirs eg; environment (contaminated water, soil), animals or infected human.
- Transmitted via direct contact, or indirect eg vectors,or direct exposure eg oral transmission.
- Human-to-human transmission by aerosolised microorganisms in droplets or physical contact eg sexual contact or blood transfusion.
- 2. Invasion
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