The Neuromuscular Junction - Medicine BM5 NLM1

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1. Activation of the nicotinic type II receptors causes what?

  • Opening of voltage-gated sodium channels
  • Activation of G-protein coupled calcium-dependent receptor
  • Opening of voltage-gated calcium channels
  • Activation of G-protein coupled sodium-dependent receptor
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2. Through what mechanism is ACh released from the presynaptic membrane?

  • Sodium-dependent endocytosis
  • Calcium-dependent endocytosis
  • Calcium-dependent exocytosis
  • Sodium-dependent exocytosis

3. Flacced paralysis is an eefect of denervation. Which of the following best describes flaccid paralysis?

  • Redistribution of ACh receptors away from motor end plates causing reactivity to ACh along the length of the muscle fibre
  • No voluntary or involuntary muscle contraction, no resting muscle tone and no active resistance to stretch
  • Muscle wasting, loss of contractile protein
  • Spontaneous twitching of motor units due to denervation hypersensitivity

4. How many sub-units make up the nicotinic type II receptors?

  • Six
  • Three
  • Five
  • Four

5. What is an end-plate potential?

  • Depolarization of the post-synaptic terminal
  • Depolarization of the motor end plate
  • Repolarization of the motor end plate
  • Repolarization of the post-synaptic terminal

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