The Neuromuscular Junction - Medicine BM5 NLM1

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1. To which sub-unit of the nicotinic type II receptor does ACh bind?

  • Gamma sub-unit
  • Alpha sub-unit
  • Beta sub-unit
  • Delta sub-unit
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2. How many sub-units make up the nicotinic type II receptors?

  • Three
  • Four
  • Five
  • Six

3. What is the NMJ?

  • The point at which neuronal activity is transduced into movement
  • The point at which acetylcholine interacts with nicotinic type 1 receptors
  • The National Monkey Journal
  • The point at which electrical activity is passed into neurons from muscles

4. Which of the following regulate motor neurone activity?

  • Dorsal root ganglia, dorsal rami & cerebellum
  • Cerebral cortex, basal ganglia & cerebellum
  • Occipital lobe, parietal lobe & dorsal root ganglia
  • Basal ganglia, dorsal root ganglia & cerebral cortex

5. What is denervation hypersensitivity?

  • No voluntary or involuntary muscle contraction, no resting muscle tone and no active resistance to stretch
  • Muscle wasting, loss of contractile protein
  • Redistribution of ACh receptors away from motor end plates causing reactivity to ACh along the length of the muscle fibre
  • Spontaneous twitching of motor units due to denervation hypersensitivity

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