The Neuromuscular Junction - Medicine BM5 NLM1

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1. Which of the following features allow the post-synaptic terminal to be an effective site of neurotransmitter reception?

  • Complex junctional folds, large surface area & lots of receptors
  • Simple junctional folds, large surface area & lots of receptors
  • Complex junctional folds, small surface area & lots of receptors
  • Complex junctional folds, large surface area & few receptors
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2. Which of the following best describes the passage of an action potential post-NMJ to muscle contraction?

  • I don't know
  • AP carried into transverse tubule system leading to calcium release and muscle contraction
  • AP causes spasm in T tubules, which leads to muscle explosion
  • Muscles don't like contracting

3. Denervation is usually associated with what?

  • Lesion of a sensory neuron
  • Lesion of a lower motor neuron
  • Lesion of an upper motor neuron
  • Breakdown of a sensory synapse

4. What is denervation hypersensitivity?

  • Redistribution of ACh receptors away from motor end plates causing reactivity to ACh along the length of the muscle fibre
  • Muscle wasting, loss of contractile protein
  • Spontaneous twitching of motor units due to denervation hypersensitivity
  • No voluntary or involuntary muscle contraction, no resting muscle tone and no active resistance to stretch

5. What is a motor unit?

  • A group of up to ten motor end plates
  • A group of muscle fibres innervated by a single motor neuron
  • A group of up to ten sarcomeres
  • A single muscle fibre

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