The Neuromuscular Junction - Medicine BM5 NLM1

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1. Flacced paralysis is an eefect of denervation. Which of the following best describes flaccid paralysis?

  • No voluntary or involuntary muscle contraction, no resting muscle tone and no active resistance to stretch
  • Redistribution of ACh receptors away from motor end plates causing reactivity to ACh along the length of the muscle fibre
  • Spontaneous twitching of motor units due to denervation hypersensitivity
  • Muscle wasting, loss of contractile protein
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2. What are the two products of the metabolism of ACh?

  • Acetic Acid & Cholinesterase
  • Acetic Acid & Choline
  • Acetyl CoA & Choline
  • Acetylcholine & Ester

3. To which sub-unit of the nicotinic type II receptor does ACh bind?

  • Alpha sub-unit
  • Delta sub-unit
  • Beta sub-unit
  • Gamma sub-unit

4. Through what mechanism is ACh released from the presynaptic membrane?

  • Sodium-dependent exocytosis
  • Sodium-dependent endocytosis
  • Calcium-dependent exocytosis
  • Calcium-dependent endocytosis

5. Activation of the nicotinic type II receptors causes what?

  • Activation of G-protein coupled sodium-dependent receptor
  • Activation of G-protein coupled calcium-dependent receptor
  • Opening of voltage-gated sodium channels
  • Opening of voltage-gated calcium channels

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