Schizophrenia and Depression

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What is neuropsychiatry concerned with?
Understanding the neural basis of psychiatric disorders
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What percentage is the prevalence in family members with schizophrenia?
10%
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What percentage is the prevalence in identical twins of patients with schizophrenia?
45%
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What is the typical age of onset for schizophrenia?
Adolescence to early adulthood
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What does the dopamine theory of schizophrenia suggest?
Excess extracellular dopamine causes schizophrenia
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Which drugs can further increase dopamine levels in someone with schizophrenia?
Cocaine and amphetamine
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What does Chlorpromazine reduce in terms of dopamine?
Activity
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How many schizophrenia patients have neuropsychological profiles in the normal range?
15-30%
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In schizophrenia there seems to be a correlation between __________ and _________
Number of negative symptoms, cognitive deficits
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Where have deficits not been seen in schizophrenia?
Short term memory
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Where is there under activation in schizophrenia patients?
DLPFC
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What is hypofrontality?
Reduced prefrontal cortex activity
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What percentage of people does depression affect at some point in their life?
10%
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What are the concordance rates of depression for identical twins?
60%
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What is the role of a selective serotonin reuptake inhibitor (SSRI)?
Stops serotonin being reabsorbed
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What is the most commonly reported cognitive deficit in depression?
Executive dysfunction
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What is mood congruent memory?
Depressed mood makes negative memories more accessible
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Which area did the depressed participants show greater activation in Siegle et al. (2007)?
Amygdala
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Which area did the depressed participants show decreased activation in Siegle et al. (2007)?
DLPFC
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What did Siegle et al. (2007) show that the DLPFC was involved in?
Regulating systems in the brain
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Card 2

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What percentage is the prevalence in family members with schizophrenia?

Back

10%

Card 3

Front

What percentage is the prevalence in identical twins of patients with schizophrenia?

Back

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Card 4

Front

What is the typical age of onset for schizophrenia?

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Card 5

Front

What does the dopamine theory of schizophrenia suggest?

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