S1W8 Bioavailability - PK

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What is bioavailability?
Fraction of a dose that reaches the systemic circulation unchanged
Often referred to as 'F'
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How does bioavailability of drugs differ by route?
IV drugs do not undergo first pass metabolism therefore bioavailability is 100%
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What are some factors affecting bioavailability?
Concentration
Formulation
Molecular size
Blood supply
Motility
Gastric content
Bile
Enteric bacteria
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What is the equation for bioavailability?
F = AUCoral/AUCiv
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What does the area under curve?
The exposure of the body to a drug over time
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Other cards in this set

Card 2

Front

How does bioavailability of drugs differ by route?

Back

IV drugs do not undergo first pass metabolism therefore bioavailability is 100%

Card 3

Front

What are some factors affecting bioavailability?

Back

Preview of the front of card 3

Card 4

Front

What is the equation for bioavailability?

Back

Preview of the front of card 4

Card 5

Front

What does the area under curve?

Back

Preview of the front of card 5

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