S2W2 Introduction to PK of biologics (PK)

Created by: Tino Muronda
Created on: 25-03-21 16:24

What is a biologic?

Any medicinal product derived from a living organism

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What is a monoclonal antibody?

lab mad proteins that mimic the immune's sysems ability to fight pathogens and flag them for destruction by immune cells

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What is the nomenclature for monoclonal antibodies?

Monoclonal antibodies end in -mab
-u - indicates fully human molecule
-lim - indicates the target is the immune system
-ada - is chosen by

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What are some examples of biologics?

Adalimumab, human growth hormone, insulin

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What are some differences between biologics and standard small molecule drugs?

Biologics have a higher molecular weight, produced using biological processes whereas small molecule drugs are produced from chemical processes
Biologics have a complex PK and small molecules drugs have a predictable one
Biologics have limited distributio

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What are first generation biologics?

Replicas of human hormones

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What are second generation biologics?

'engineered' proteins
Gene altered to change the structure of the biologic protein

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What are third generation biologics?

Large molecules designed for a specific biological process

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What are fusion proteins?

Produced by linking two or more genes to produce a combined protein

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What are some physio-chemical properties of biologics?

Often several fold larger than conventional small molecule drugs
behave different to other drugs due to protein folding and denaturation differences

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Where is the major route of absorption for biologics?

Lymphatics

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What are some PK features of biologics?

Small Vd
Elimination process is endocytosis, proteolysis

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Other cards in this set

Card 2

Front

What is a monoclonal antibody?

Back

lab mad proteins that mimic the immune's sysems ability to fight pathogens and flag them for destruction by immune cells

Card 3

Front

What is the nomenclature for monoclonal antibodies?

Back

Card 4

Front

What are some examples of biologics?

Back

Card 5

Front

What are some differences between biologics and standard small molecule drugs?

Back

View more cards

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S2W2 Introduction to PK of biologics (PK)