How to work out out the amount of a drug in the body in mg?
Voulme (L) x Concentration (mg/L)
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How to work out initial concentration?
Dose (mg) / Volume (L)
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How to work out the concentration at certain time (t)?
Initial concentration x e^CL/V x t
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How to calculate half life?
ln(2)V/CL
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How to calculate the concentration with the infusion rate at steady state?
infusion rate / CL
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What properties of the time-concentration profile are important for determining drug effect?
AUC
Peak (Cmax)
Slope (elimination and absorption)
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What is steady-state?
When the amount of drug in the plasma has built up to a level that is therapeutically effective and as long as regular doses are being administered to balance the amount of the drug being cleared the drug will remain active.
Administration and elimination
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How to work out infusion rate?
Concentration x CL
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What is infusion rate?
The desired rate a drug should be administered to achieve steady state of a fixed dose
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How is a therapeutic concentration reached quickly?
Loading dose
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How do you calculate loading dose?
Desired concentration x Vd
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How to work out mean concentration at steady state by intermittent infusion?
CPss = Dose/Cl x t(dosing interval)
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What are the differences between an oral conc-time graph and an IV conc-time graph?
Oral has a longer time to reach peak concentration and the peak is lower due to bioavailability
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What is intermittent infusion?
Infusion of a volume of drug over a set period of time of prescribed intervals and then stoped until the next dose is required
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When might a bolus or loading dose be required?
In an emergency
When elimination of a drug is slow
When you want to reach desired therapeutic effect quickly
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How to calculate mean concentration at stead state by intermittent infusion of a non-IV drug?
CPss = Dose x F / CL x dosing interval
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Other cards in this set
Card 2
Front
How to work out initial concentration?
Back
Dose (mg) / Volume (L)
Card 3
Front
How to work out the concentration at certain time (t)?
Back
Card 4
Front
How to calculate half life?
Back
Card 5
Front
How to calculate the concentration with the infusion rate at steady state?
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