S1W8 Bioavailability - PK 0.0 / 5 ? OtherPharmacokineticsUniversityNone Created by: Tino MurondaCreated on: 17-05-21 17:11 What is bioavailability? Fraction of a dose that reaches the systemic circulation unchanged Often referred to as 'F' 1 of 5 How does bioavailability of drugs differ by route? IV drugs do not undergo first pass metabolism therefore bioavailability is 100% 2 of 5 What are some factors affecting bioavailability? Concentration Formulation Molecular size Blood supply Motility Gastric content Bile Enteric bacteria 3 of 5 What is the equation for bioavailability? F = AUCoral/AUCiv 4 of 5 What does the area under curve? The exposure of the body to a drug over time 5 of 5
Comments
No comments have yet been made