S1W5 Concetration and response - PK 0.0 / 5 ? OtherPharmacokineticsUniversityNone Created by: Tino MurondaCreated on: 17-05-21 16:25 What is ADME? Absorption, Distribution, Metabolism and Excretion 1 of 6 What does pharmacological effect depend on? Active molecule reaching the site of action Adequate concentration at the site of action 2 of 6 What are some pharmacokinetic factors that determine concentration of a drug at its target? Solubility and permeability of the drug A meal Chemical characteristics of a drug Blood flow to organs Enzyme activity Organ function Age 3 of 6 What is the therapeutic index? The ratio between EC50 and TC50 4 of 6 What is EC50? The concentration of a drug that gives half the maximal response 5 of 6 What is TC50? Dose at which toxicity occurs at 50% of cases 6 of 6
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