S1W5 Concetration and response - PK

?
What is ADME?
Absorption, Distribution, Metabolism and Excretion
1 of 6
What does pharmacological effect depend on?
Active molecule reaching the site of action
Adequate concentration at the site of action
2 of 6
What are some pharmacokinetic factors that determine concentration of a drug at its target?
Solubility and permeability of the drug
A meal
Chemical characteristics of a drug
Blood flow to organs
Enzyme activity
Organ function
Age
3 of 6
What is the therapeutic index?
The ratio between EC50 and TC50
4 of 6
What is EC50?
The concentration of a drug that gives half the maximal response
5 of 6
What is TC50?
Dose at which toxicity occurs at 50% of cases
6 of 6

Other cards in this set

Card 2

Front

What does pharmacological effect depend on?

Back

Active molecule reaching the site of action
Adequate concentration at the site of action

Card 3

Front

What are some pharmacokinetic factors that determine concentration of a drug at its target?

Back

Preview of the front of card 3

Card 4

Front

What is the therapeutic index?

Back

Preview of the front of card 4

Card 5

Front

What is EC50?

Back

Preview of the front of card 5
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