Pharmacology lecture 15

HideShow resource information
What contains the NAergic cell bodies?
Locus coeruleus
1 of 30
Where do the noradrenergic pathways project to?
Hypothalamus, midbrain, hippocampus and cortex
2 of 30
What contains serotonergic cell bodies?
Dorsal and median raphe nuclei
3 of 30
Where do the serotonergic pathways project to?
Hypothalamus, hippocampus and cortex
4 of 30
What is NA and 5-HT metabolised by?
MAOa and MAOb
5 of 30
NA receptors: What do the alpha 1 receptors do?
Stimulate PI cycle (excitatory)
6 of 30
NA receptors: What do the alpha 2 receptors do?
Inhibit adenylate cyclase, opens K+ channels
7 of 30
NA receptors: What do the beta 1,2,3 receptors do?
Stimulate adenylate cyclase
8 of 30
Name the 5-HT receptors? What kind of receptor is it?
1A, 1B, 1D, 1E, 1F, 2A, 2C, 3, 4, 5, 6, 7. G-protein linked
9 of 30
What do the 5-HT1 (A-F) do?
Inhibit adenylate cyclase
10 of 30
What do the 5-HT2(A,C) do?
Stimulate PI cycle
11 of 30
What do autoreceptors in the terminals of NA and 5-HT do? What receptors are they?
Inhibit transmitter release. NA terminal auto receptors are alpha 2. 5-HT terminal receptors are 5-HT1B
12 of 30
What do autoreceptors in the cell bodies of NA and 5-HT do? What receptors are they?
Inhibit firing. NA cell body auto receptors are alpha 2. 5-HT cell body auto receptors are 5-HT1A.
13 of 30
What is responsible for termination of neurotransmitter effects?
Monoamine reuptake transporters
14 of 30
What does Iproniazid inhibit?
MAO
15 of 30
What does Imipramine inhibit?
NA/5-HT reuptake
16 of 30
What are MAOIs?
Monoamine inhibitors
17 of 30
What do the MAOIs do?
Inhibit intracellular metabolism of 5-HT. INCREASE vesicular 5-HT. INCREASE 5-HT release.
18 of 30
Name the types of MAOIs
Reversible (MAOa), irreversible (MAOa/b), selective, non-selective
19 of 30
What are the side effects of MAOIs?
INCREASE DA transmission. INCREASE actions of sympathomimetic amines (cheese reaction)
20 of 30
What is the cheese reaction?
Tyramine and other amines are normally metabolised by MAO. With MAOIs amine levels INCREASE. They act as indirect sympathomimetics provoke HYPERTENSIVE crisis
21 of 30
What do monoamine reuptake inhibitors do?
Prevent removal of transmitter from synaptic cleft. Levels of transmitter in cleft INCREASE. Magnitude and duration of receptor activation INCREASE
22 of 30
What are the properties of selective MAOIs?
Fewer side effects. Lower efficacy
23 of 30
What are the properties of reversible MAOIs?
Lower interaction with other antidepressants. Lower efficacy
24 of 30
What do tricyclic antidepressants do? What are the side effects?
Inhibit reuptake of 5-HT and NA. H1 antagonism - sedation. mAch antagonism - dry mouth. alpha1 antagonism - postural hypotension
25 of 30
What is the serotonin syndrome?
Synergistic INCREASE in synaptic 5-HT provokes malignant hyperthermia.
26 of 30
What are the 3 theories of delayed antidepressant action?
1) Postsynaptic receptor adaptation 2) Desensitisation of autoreceptors 3) Synaptic remodelling
27 of 30
What happens during postsynaptic receptor adaptation?
Increase of synaptic levels of transmitter causes desensitisation of receptors. Desensitisation crucial in the therapeutic response.
28 of 30
What happens during desensitisation of autoreceptors?
ADs inhibit firing and terminal release via auto receptors. Synaptic 5-HT levels NOT increased. Auto receptors desensitise firing and terminal release are restored --> synaptic 5-HT increases
29 of 30
What happens during synaptic remodelling?
ADs cause increase in 5-HT. This increase causes synaptic remodelling (5-HT is a trophic factor) which takes time
30 of 30

Other cards in this set

Card 2

Front

Where do the noradrenergic pathways project to?

Back

Hypothalamus, midbrain, hippocampus and cortex

Card 3

Front

What contains serotonergic cell bodies?

Back

Preview of the front of card 3

Card 4

Front

Where do the serotonergic pathways project to?

Back

Preview of the front of card 4

Card 5

Front

What is NA and 5-HT metabolised by?

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Biology resources:

See all Biology resources »See all Antidepressants: drugs in the treatment of depression resources »