pharmacology 1

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What is pharmacology
the study/ science of chemicals (drugs) that interact with the human body
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what is pharmacodynamics
what a drug does to the body (biological effects and mechanism of action)
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what is pharmacokinetics
what the body does to a drug (absorption, distribution, metabolism and the excretion of drugs and their metabolites)
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what is pharmacy
the science and technique of preparing, dispensing and reviewing of medicinal drugs
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what is a medicine
a chemical preparation containing one or more drugs used with the intention of causing a therapeutic effect. medicines usually include. agents additional to the active drug. for a drug to be useful as a therapeutic agent, it must act with. a degree o
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how do drugs act?
act by biding to target molecules
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where does selectivity result from
the chemical structure of the drug (biding site specificity) the target recognising only ligands of a precise structure (ligand specificity)
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what do drugs bind to
enzymes,carrier molecules, ion. channels , receptors
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what are receptors
macromolecules/ proteins which are normally activated by transmitters or hormones and mediate a biological action
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What is an angonist and an antagonist?
agonist: a drug/chemical that activates a receptor and causes a response. antagonist: a type of drug which combines with a receptor but does not activate it , thus blocking the action of the agonist by biding to the same receptor
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what do agonist posses?
affinity and efficacy
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what is affinity?
strength of association between ligand and receptor
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what does a low and high affinity mean
low: fast dissociation rate high: slow dissociation rate
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what is efficacy
the ability of an agonist to evoke a cellular response
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what do antagonists possess and lack?
posses: affinity lack: efficacy
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how.would the relationship between conc or dose and response be described
hyperbolic or sigmoidal
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what is EC50
the conc of agonist that elicits a half maximal response
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what is the name given when an agonist and antagonist occur at the same time
orthosteric
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what kind of curve is caused by competitive antagonists
parallel shift of the dose response curve with no depression of the maximal repose
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what kind of curve is caused by non. competitive antagonists
depressed curve. and max. conc response. curve but do not cause a rightward shift
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Other cards in this set

Card 2

Front

what is pharmacodynamics

Back

what a drug does to the body (biological effects and mechanism of action)

Card 3

Front

what is pharmacokinetics

Back

Preview of the front of card 3

Card 4

Front

what is pharmacy

Back

Preview of the front of card 4

Card 5

Front

what is a medicine

Back

Preview of the front of card 5
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