Body’s own immune system reacting to target cell’s antigens.
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what are the aetiology of autoimmune disease
- genetics
- environmental trigger
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talk about the following autoimmune diseases briefly
type 1 diabetes
autoimmune haemolytic anaemia
immune thrombocytopenia purpura (ITP)
Multiple sclerosis
coeliac disease
primary Hillary cirrhosis
pemphigus vulgaris
mucous membrane pemphigoid
psoria
A: autoimmune condition in which T cells attack and destroy beta cells in the pancreas that produce insulin
B: antibodies destroy the persons’ own RBC (To burst, leading to anaemia)
C: autoimmune condition, where the spleen produces Igg autoantibodies dir
what does does DMARDS stand for and what do they do
Disease Modifying Anti-Rheumatic Drugs (aka Conventional DMARDs)
Press the immune system and slow or stop the progression. Treat the disease not just mask the symptoms
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what do biologics do
target one aspect of the immune system compared to supressing the entire immune system like DMARDS.
Biologics are proteins and are produced by living organisms or bio-engineering by recombinant DNA technologies. They have to be administered by IV infusio
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what do corticosteroids do
Suppress immune system, reduce inflammation and decrease the autoimmune response
They bind to the intracellular glucocorticoid receptor- cascade of altering numerous cell functions to bring about immune suppression. Predominantly affecting the innate immu
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what is prednisolone oral given for
taken to control acute flares in autoimmune conditions or at the time of diagnosis and the disease is poorly control- to decrease the inflammation rapidly. Quick relief
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what are the side effects of corticosteroids
Hypertension, impaired diabetes control, hyperglycaemia (with or without history of DM), osteoporosis, increasing weight, peptic ulcers, bruising, mood swings )
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what should be monitored in someone who's taking corticosteroids
BP, hyperglycaemia
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what are the oral side effects of corticosteroids
Increases susceptibility to infection
Candidosis
MRONJ – see SDCEP guidance
Prophylaxis:
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what conditions are treated by DMARDS in general medicine
what are the dental consideration in patients who take DMARDS
Increased susceptibility to infection (look out for TB and latent/atypical dental infections . because they suppress immune system
They do chest X rays to make sure patient doesn’t have latent TB which can become active when the immune system is supres
Increased risk of infection:
o Biologics should be discontinued in the presence of serious infection
o Look out for TB and latent/atypical dental infections
• Neutropenia, thrombocytopenia because of bone marrow failure. Increased risk of bleeding
• Si
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Other cards in this set
Card 2
Front
what are the aetiology of autoimmune disease
Back
- genetics
- environmental trigger
Card 3
Front
talk about the following autoimmune diseases briefly
type 1 diabetes
autoimmune haemolytic anaemia
immune thrombocytopenia purpura (ITP)
Multiple sclerosis
coeliac disease
primary Hillary cirrhosis
pemphigus vulgaris
mucous membrane pemphigoid
psoria
Back
Card 4
Front
What is the pharmacological management/ treatment
Back
Card 5
Front
what does does DMARDS stand for and what do they do
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