modulators of neuronal excitability

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1. 5HT3 is an ionotropic receptor.
5HT3 receptor activation allows for the flow of cations into the cell. 5HT3 receptor activation results in what

  • depolarisation
  • hyperpolarisation
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2. select the example of a modulator of a voltage gated calcium channel

  • CARBAMAZEPINE
  • ETHOSUXIMIDE
  • RETIGABINE
  • PHENYTOIN

3. where are 5HT3 receptors expressed: select incorrect answer

  • Hypothalamus inhibiting the activity of afferents connected to neurons in the CTZ.
  • Vagal nerve afferents
    carry information from stomach to the brain including to the vomiting centre
  • The chemoreceptor trigger zone (CTZ)
    The CTZ is located in the medulla oblongata
    receives inputs from blood-borne drugs or hormones
    The CTZ communicates with other structures in the vomiting centre to initiate vomiting

4. what type of voltage-activated channels does ethosuximide hit?

  • low
  • high

5. WHAT NERVE ENDINGS DOES SUMATRIPTAN ACT ON

  • Trigeminal
  • BUSPIRONE
  • Frontal cortex
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