7. a Modulators of voltage-gated (VG) Na channel, includes what drug?
PHENYTOIN
ETHOSUXIMIDE
GABAPENTIN
RETIGABINE
8. name a mixed modulator working at D2 receptors and 5HT3 receptors
HALOPERIDOL
ONDANSETRON
METOCLOPRAMIDE
RISPERIDONE
9. what subunit does GABAPENTIN bind to?
α2δ
b2
a1
a2
10. select the example of a modulator of a voltage gated calcium channel
PHENYTOIN
RETIGABINE
ETHOSUXIMIDE
CARBAMAZEPINE
11. name a modulators of VG Potassium channels
GABAPENTIN
RETIGABINE
ETHOSUXIMIDE
CARBAMAZEPINE
12. NAME ANOTHER Modulators of VG Na channel
ETHOSUXIMIDE
GABAPENTIN
CARBAMAZEPINE
RETIGABINE
13. CARBAMAZEPINE results in what change in neuronal excitability?
decrease
increase
14. where are 5HT3 receptors expressed: select incorrect answer
The chemoreceptor trigger zone (CTZ)
The CTZ is located in the medulla oblongata
receives inputs from blood-borne drugs or hormones
The CTZ communicates with other structures in the vomiting centre to initiate vomiting
Hypothalamus inhibiting the activity of afferents connected to neurons in the CTZ.
Vagal nerve afferents
carry information from stomach to the brain including to the vomiting centre
15. Kv are opened in response to depolarisation (inside of the cell becoming more positive) of the membrane during an action potential, This results in K+ ions (positive charge) leaving the cell. This loss of positive charge results in the inside of the cell
decreased
increased
16. which drug is a mixed 5-HT and Dopamine receptor modulator, that works against schizophrenia
METOCLOPRAMIDE
RISPERIDONE
ONDANSETRON
HALOPERIDOL
17. what Decrease the release of pain and inflammatory mediators from trigeminal nerve endings
2) Cause vasoconstriction of intracranial arteries, counteracting vasodilation associated with headaches.
Triptans
benzodiazepines
18. small depolarisations of the plasma membrane, leads to membrane what and opening of voltage-gated ion channels
depolarisation
hyperpolarisation
19. which 5HT receptor is ionotropic and excitatory
5HT3
5HT2
5HT1
20. ethosuximide is activated by what depolarisations of the plasma membrane