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6. name a 5HT3 modulator

  • ONDANSETRON
  • HALOPERIDOL
  • RISPERIDONE

7. a Modulators of voltage-gated (VG) Na channel, includes what drug?

  • PHENYTOIN
  • ETHOSUXIMIDE
  • GABAPENTIN
  • RETIGABINE

8. name a mixed modulator working at D2 receptors and 5HT3 receptors

  • HALOPERIDOL
  • ONDANSETRON
  • METOCLOPRAMIDE
  • RISPERIDONE

9. what subunit does GABAPENTIN bind to?

  • α2δ
  • b2
  • a1
  • a2

10. select the example of a modulator of a voltage gated calcium channel

  • PHENYTOIN
  • RETIGABINE
  • ETHOSUXIMIDE
  • CARBAMAZEPINE

11. name a modulators of VG Potassium channels

  • GABAPENTIN
  • RETIGABINE
  • ETHOSUXIMIDE
  • CARBAMAZEPINE

12. NAME ANOTHER Modulators of VG Na channel

  • ETHOSUXIMIDE
  • GABAPENTIN
  • CARBAMAZEPINE
  • RETIGABINE

13. CARBAMAZEPINE results in what change in neuronal excitability?

  • decrease
  • increase

14. where are 5HT3 receptors expressed: select incorrect answer

  • The chemoreceptor trigger zone (CTZ)
    The CTZ is located in the medulla oblongata
    receives inputs from blood-borne drugs or hormones
    The CTZ communicates with other structures in the vomiting centre to initiate vomiting
  • Hypothalamus inhibiting the activity of afferents connected to neurons in the CTZ.
  • Vagal nerve afferents
    carry information from stomach to the brain including to the vomiting centre

15. Kv are opened in response to depolarisation (inside of the cell becoming more positive) of the membrane during an action potential, This results in K+ ions (positive charge) leaving the cell. This loss of positive charge results in the inside of the cell

  • decreased
  • increased

16. which drug is a mixed 5-HT and Dopamine receptor modulator, that works against schizophrenia

  • METOCLOPRAMIDE
  • RISPERIDONE
  • ONDANSETRON
  • HALOPERIDOL

17. what Decrease the release of pain and inflammatory mediators from trigeminal nerve endings
2) Cause vasoconstriction of intracranial arteries, counteracting vasodilation associated with headaches.

  • Triptans
  • benzodiazepines

18. small depolarisations of the plasma membrane, leads to membrane what and opening of voltage-gated ion channels

  • depolarisation
  • hyperpolarisation

19. which 5HT receptor is ionotropic and excitatory

  • 5HT3
  • 5HT2
  • 5HT1

20. ethosuximide is activated by what depolarisations of the plasma membrane

  • small
  • large