Heroin

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Mode of Action
heroin mimics endorphins at the synapse by inhibiting the release of GABA which is in charge of preventing the production of dopamine so mood is regulated. this causes euphoria. area affected is the nucleus accumbens
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Short Term Effects
euphoria, lessening of pain, sleepiness
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Long Term Effects
hepatitis C and restricted breathing
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Tolerance
builds up quickly and cross-tolerance to other opioids. down regulation (reduction in receptor site as excess dopamine is detected)
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Physical Dependence
builds up quickly
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Withdrawal
lasts for around a week after ceasing use of heroin. includes insomnia, depression, pain and anxiety
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agonist or antagonist?
agonist: increases frequency of post-synaptic responses
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depressant or stimulant?
depressant
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Card 2

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Short Term Effects

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euphoria, lessening of pain, sleepiness

Card 3

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Long Term Effects

Back

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Card 4

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Tolerance

Back

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Card 5

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Physical Dependence

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