where does the liver receive blood- with proportions
75% from hepatic portal vein. deoxygenated from digestive system. 25% from hepatic artery, oxygenated from aorta
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what are sinusoids
no capillarys- enodthelium lined spaces. kpuffer cells as phagocytes also
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liver functions-7
1. bile production 2. decomp of rbc and production of bilirubin 2. detox and metabol of xenobiotics 3. storage of glycogen, vitimans, copper and iron 4. metab of carbs 5. protien synthesis 6.hormone production
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describe carb metabolism
stored as glycogen. converted to gluose when required. if glycogen stores =0 then cori and alanine cycle take place. glucse regulated by hormone production
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describe lipid metabolism
glucose- aceytl co a - fatty acid. cholesteral also produced
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describe bile production
bile acid produced from cholesterol. linked to amino acids to then produce bile salts. used in lipid digestion
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describe phase i of first pass metabolism
compound made polar by adding functional groups, oxidaistion occurs via p450 enzyme
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describe phase ii
conjugation with endogenous substrate to increase solubility eg with glucoronice via glucuronidation
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why are liver enzymes used
raised levels act as biomarkers of disease
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what enzymes used, what does it show
transaminase enzymes- alt and ast- rise during acute liver damage. chloestatic enzymes . alp shows biliary tract damage. ggt shows alcohol toxicity
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other biomarker of liver?
billirubin levels- high shows liver isnt working correctly
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Other cards in this set
Card 2
Front
what are sinusoids
Back
no capillarys- enodthelium lined spaces. kpuffer cells as phagocytes also
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