two examples of ionotropic receptors and how they work
1. nictone acteylcholine receptors- signal ACh binds to chanel and allows nicotine to bind. influx of Na+ ions 2. Gaba A receptor-inhibitory, binds and influx of Cl- ions
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describe metatrophic receptor (muscarnic) with example
indirectly linked with ion chanles through signal transduction and g protiens. eg Gaba B
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explain how g protien is activated
signal interacts with receptor, g protien couples with the receptor and an enzyme. the enzyme then ctivates itself and goes on to activate the g protien
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how many transmembrane domains does the receptor have
7
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describe subunits of g protien
alpha, beta and gamma
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whats on alpha subunit?
a GTP/GDP binding site
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describe different affinities for each and the natural state
aplha GDP is rest state. it was high affinity for betta gamma subunits. alpha GTP has low affinity for betta gamma subunits
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describe the g protien cycle (6)
1.signal binds to receptor 2. receptor g protien interaction- g protien activates 3. GDP to GTP conversion 4.alpha subunit liberation 5. alpha subunits activates AC 6.signal eg adreniline unbinds, GTP hydrolysis
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what is AC
adenine cylase protienwhich produces ATP t be converted to cAMP
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PKA structure
protien with 4 polypeptide chains- 2 catalytic and 2 regulatory.
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cAMPs role in PKAs activation
cAMP binds to the regultory units of PKA, units dissocates, catalyitic units activated
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what does activated PKA do
catalysed the phosphorilation of protiens, leads to cellular response
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PDEs role in regulation of PKA
Cataylses the dissociation of cAMP off PKA so innactivates it
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Other cards in this set
Card 2
Front
role of transducer
Back
membrane protiens whih acts to translate extracellular singals to evoke intracellular response
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