Lysosome proteins glycosylated and manose-6 residue phosphorylated
Residue identified by M6P receptor on trans-golgi domain
Receptor changes conformation
Clatharin binds to cytoplasmic domain = mesh-like pit around receptor
= Vesicle coated in clatharin
Clatharin subunits dissociate and vesicles form early lysosome w/ low pH
Low pH caused by association between manose-6P and protein to be lost
M6P receptor recycled back to golgi
Transport vesicle formed around protein
= LYSOSOME
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