Drug Absorption & Distribution

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1. Migraine, diabetic neuropathy

  • causes gastric stasis which decreases drug absorption
  • decreases splanchnic blood flow
  • causes gastric stasis which increases drug absorption
  • causes gastric stasis which increases plasma concentration
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Other questions in this quiz

2. The effect of coeliac disease:

  • affects muscarinic receptors
  • decreases drug absorption
  • digoxin decreased, propranolol increased
  • digoxin increased, propranolol decreased

3. The number of molecules crossing the membrane per unit area per unit time, and the concentration difference across the membrane. Is known as the?

  • solubility coefficient
  • permeability coefficient
  • diffusion coeffecient
  • partition coefficient

4. Lipid insoluble:

  • Unionised
  • Ionised / Charged
  • Charged
  • Unionised / Uncharged

5. Plasma compartment:

  • Drug has large MW, or binds extensively to plasma proteins. Too large for slit junctions and is therefore trapped.
  • Drug has low MW but is hydrophilic, can move through slit junctions but not through lipid membranes
  • Drug has low MW and is hydrophobic , can move through slit junctions and cross cell membranes
  • Drugs do not enter this water compartemnt

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