CONTROL OF INSULIN SECRETION

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MECHANISM OF INSULIN SECRETION
1) At normal blood gluc conc, potassium ion channels in beta cells are open.
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Potassium ions diffuse out of cell
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Inside of cell is -70mv
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When blood gluc conc is high, glucose enters cell via glucose transporter
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Glucose metabolised inside mitochondria= ATP
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ATP binds to ATP sensitive potassium ion channels
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Potassium ion channels close and potassium ions stay inside = -30mv
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Causes volatage gated calcium channels to open
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Calcium ions enter cell
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Vesicles containing insulin bind to the plasma membrane to release insulin by EXOCYTOSIS
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Card 2

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Potassium ions diffuse out of cell

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2

Card 3

Front

Inside of cell is -70mv

Back

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Card 4

Front

When blood gluc conc is high, glucose enters cell via glucose transporter

Back

Preview of the back of card 4

Card 5

Front

Glucose metabolised inside mitochondria= ATP

Back

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