Sleep - measurements + functions 0.0 / 5 ? Human BiologySleepUniversityNone Created by: JoannaCreated on: 04-12-13 18:30 Sleep deprivation Partial / total prevention of sleep: increased irritability difficulty in concentrating episodes of disorientation effects : vary w/ age + other factors 1 of 5 Sleep recovery Sleeping more > normally after period of deprivation Night one: stage 4 sleep = increased stage 2 decreased Night two: most recover of REM sleep more intense > normal w/ rapid eye movements 2 of 5 Narcolepsy Study of narcolepsy - hypothalamic sleep center. Sufferers: -frequent sleep attacks -excessive daytime sleepiness -dont go thru SWS before REM sleep Cataplexy:- -sudden loss of muscle tone -sufferer collapse 3 of 5 Narcoleptic dogs example Mutant gene for hypocretin receptor. Hypocretin [orexin] -prevents transition from wakefulness directly into REM sleep - interfere w/ hypocretin signaling - leads to narcolepsy 4 of 5 Hypocretin Hypocretin neurons in hypothalamus - project to other brain centers: the basal forebrain the reticular formation locus coeruleus Axons - go to tuberomamillary nucleus inhibition induces SWS Hypothalamic hypocretin sleep center: act as a switch controls wakefulness controls SWS sleep / REM sleep 5 of 5
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