Cell Mediated Immunity
- Created by: Jack
- Created on: 04-05-15 10:45
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- Cell Mediated Immunity
- High specificity
- Slow reaction
- Quicker on secondary exposure
- Develops memory
- Quicker on secondary exposure
- Intracellular Microbes
- Viruses and some bacteria
- Bacteria: Mycobacterium tuberculosis Listeria monocytogenes
- Viruses Herpes simplex virus
- Protozoa: Trypanosoma brucei (sleeping sickness)
- Helminths: Leishmania sp.
- Viruses and some bacteria
- Mediated by T lymphocytes
- 2 effector esponses
- Cytotoxic T cell production
- Delayed Type Hypersensitivit (DTH) responses
- Naive CD4+ T-cell
- Antigen signal - MHCII - restricted
- Co-stimulatory signal
- Cytokines - polarisation
- IL-12, IFN-gamma
- Th1 cells
- Co-stimulatory signal
- Antigen signal - MHCII - restricted
- Effector functions
- Macrophage activation
- Cytotoxic T-cell activation / differentiation
- B cell activation: antibodies for opsonisation / clearance
- Neutrophil activation
- Cytotoxic T-cells
- CD8+
- Antigen signal - MHCI - restricted, Co-stimulatory signal
- CD4+ T-cells
- Th1 cells
- IFN-gamma, IL-2
- Cytotoxic T-cell production
- Antigen signal - MHCI - restricted, Co-stimulatory signal
- Perforin and Granzyme
- Soluble Killing
- IFN-gamma, TFN-beta
- Fas-ligand
- Membrane bound killing
- Cytotoxic T-cell production
- IFN-gamma, IL-2
- Th1 cells
- CD8+
- DTH
- Often against pathogens inside macrophages
- Recruit monocytes
- Keep monocytes at site
- Activate monocytes
- Keep monocytes at site
- Th1 + IFN-gamma + TNF-alpha + IL-2
- Macrophage activation
- Amplification loop
- Th1 + IFN-gamma + TNF-alpha + IL-2
- Macrophage activation
- Amplification loop
- Retained at site by macrophage inhibition factor (MIF)
- Amplification loop
- Macrophage activation
- Th1 + IFN-gamma + TNF-alpha + IL-2
- Retained at site by macrophage inhibition factor (MIF)
- Amplification loop
- Macrophage activation
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