P: Side effects of the psychoactive drugs can be severe.
E: NHS Website - Side effects are unwanted symptoms caused by medical treatment and can range from mild, such as drowsiness or feeling sick to severe with life-threatening conditions, however, these do vary from person to person and there is a chance you won't experience these.
However, in common cases of people taking SSRIs, side effects for people can include sleeping problems, loss of appetite, blurred vision, being sick, excessive sweating, etc... These can be as severe as leading to hallucinations, vomiting blood, or suicidal thoughts.
E: Therefore, when a patient who is suffering from depression and is taking SSRIs to try and gain a better quality of life and then experience side effects as severe as suicidal thoughts, it's not having any benefit to their mental health and isn't effective as it could be. Furthermore, it might lead the patient to stop taking their medication in order to avoid further side effects.
L: In these cases of the severity of side effects, biological therapies are not successful in treating mental illness, and doctors or psychiatrists might recommend a different therapy e.g. CBT to relieve symptoms
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