- Skeletal muscle consists of muscle fibres, which are multinucleate and possess many mitochondria, extensive saroplasmic reticulum (storage of calcium ions) and infoldings of the cell-surface membrane
- Muscle fibres comprise myofibrils consisting of actin (thin) and myosin (thick) filaments. Each myofibril has recognisable repeating units called sarcomeres, each of which contains overlapping filaments of actin and myosin
- Contraction of the sarcomere (and muscle) involes the following:
- the release of calcium ions unblocks the binding sites on the actin filaments
- myosin heads attach to the actin forming acto-myosin bridges
- the bridges rotate, pulling the actin filaments over the myosin filaments
- ATP allows myosin to detach and the cycle of attachment-rotation-detachment is repeated
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