Monoclonal antibodies

Monoclonal antibodies

  • Mouse injected with antigen that is being targeted
  • Mouse reponds by producing lymphocytes (white blood cells that make antibodies)
  • They then start making an antibody agaisnt the target antigen
  • Lymphocytes are then harvested from the mouse
  • Lymphocytes are combined with tumour cells (lymphocytes don't divide easily) then the tumour cells copy themselves 
  • When combined - they are called hybridoma cells
  • Hybridoma cells reproduce rapidly to make clone cells
  • Clone of identical cells all make some type of antibody
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