Karp and Frank

The aim of this study was to compare drug treatment or therapy alone, with a combination of drug treatment and therapy, to treat depression in women.

The participants were various samples of women and men with depression from 1974 to 1992 who met the DSM criteria for depression. 

The method was a review of many studies which each had 2 conditions, such as drug and placebo, therapy and placebo, and therapy plus drugs. 

The procedure involved analysing depression using inventories such as the Beck Depression Inventory (BDI), patients were tested before and after treatment. 

The results showed that very little evidence was found to suppport the effectiveness of combination therapy over either therapy or drug therapy alone for women patients.