It is estimated that in the UK 45% of deaths from coronary heart disease in men and 47% iof deaths from coronary heart disease in women are due to a raise blood cholesterol level. It is thought that 10% of deaths from coronary heart disease in the UK could be avoided if everyone had a blood cholesterol level of less than 6.5 nmol/l.
Like all lipids, cholestrol is not solube in water. In order to be transported in the bloodstream, insoluble cholesterol is combined with proteins to form soluble lipoproteins.
There are two major transport lipoproteins:
- low-density lipoproteins (LDLs) - the main cholesterol carrier in the blood. The triglycerides from saturated fats in our diet combine with cholestrol and protein to form LDLs. These circulate in the bloodstream and bind to receptor sites on cell membranes before being taking up by the cells. Excess LDLs in the diet overload these membrane receptors, resulting in high blood cholesterol levels. Saturated fats may also reduce the activity of LDL receptors so the LDLs are not rememoved from the blood, thus further increasing the blood cholesterol levels. This cholesterol may be deposited in the artery walls forming atheromas.
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