Antibodies - made from proteins, four polypeptide chains.
- Heavy chains - long
- Light chains - short
They can change shape to fit around the antigen. Antigen-antibody complex, the binding site is different on each antibody - variable region. The rest of the antibody is the same - constant region - binds to the B cells.
Monoclonal antibodies
Each antigen will induce a different B cell to divide, each of these clones will produce a different antibody - polyclonal antibodies.
Medical value to produce antibodies outside the body, a single type of antibody being cloned is a monoclonal antibody. These can help science:
- separation of chemicals from mixtures
- immunoassay - calculating amount of substance in a mixture - pregnancy tests
- cancer treatment - monoclonal antibodies can be made to attach onto cancer cells - destroyed
- transplant surgery - usually rejected due to the T cells action, but monoclonal antibodies can knock out these T cells.
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