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DRUG THERAPY
(events at the synapse)
1. Vesicles contain
neurotransmitters
2. Fusion with PRESYNAPTIC
membrane
3. Neurotransmitters diffuse
across the synapse
4. Neurotransmitters bind
with receptors in
POSTYNAPITC membrane
5. Back into the neuron…read more

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Monoamine Oxidase Inhibitors (MAOI's)
Chemical name: Phenelzine
Brand name: Nardil
- MAOIs prevent monoamine oxidase from breaking down the
monoamines
- Monoamines remain longer in the synapse
- More binding with POSTSYNAPTIC receptors…read more

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Monoamine Oxidase Inhibitors (MAOI's)
Chemical name: Phenelzine
Brand name: Nardil
· Need to restrict diet
· Used when other drugs fail to work
Drowsiness, Constipation, Nausea, Diarrhoea, Stomach upset, Fatigue,
Dry mouth, Dizziness, Low blood pressure, Light-headedness
(especially when getting up from a lying or sitting position), Decreased
urine output, Decreased sexual function, Sleep disturbances, Muscle
twitching, Weight gain, Blurred vision, Headache, Increased appetite,
Restlessness, Shakiness, Trembling, Weakness, Increased sweating.…read more

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Trycyclics
Chemical name:Imiramine
Brand name: Tofranil
http://www.youtube.com/watch?
v=ocSptPUBbuo&feature=related
Slows down absorption
by pre-synaptic
vesicles
Neurotransmitter
remains longer in
synaptic cleft…read more

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Trycyclics
Chemical name:Imiramine
Brand name: Tofranil
Stern et al: more
effective in severe
· Effective in alleviating depression
symptoms of depression
· Fewer side-effects than Severe patients=
greater imbalance
MAOIs
Side-effects includes:
dizziness, blurred vision, Did not work as
dryness of the mouth, placebo
tremors sexual problems,
drowsiness, skin rash, and weight
gain or loss.
It can also impair driving to
a dangerous extent…read more

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