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Glycolysis…read more

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Glycolysis
· Glycolysis occurs in the cytoplasm of a cell
· Pathway of Glycolysis involves 10 stages, however for
a2 we just need to know an outline. Each stage has
specific enzymes to catalyse each reaction.
So pyruvate is in the cytoplasm. However ATP is used to pump
pyruvate into the matrix of the mitochondria. ACTIVE TRANSPORT.
So the LINK REACTION takes place in the matrix!!!…read more

Slide 4

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The process of Glycolysis
· Stage 1: phosphorylation
Glucose [6c]
ATP hydrolysed: glucose phosphorylated (destabilises
glucose)
Glucose-6-phosphate [6c+pi]
Isomerisation by
isomerases
Fructose-6-
phosphate [6c+pi]
ATP
ATP energy activates the Hexose sugar (Hexose/fructose bisphosphate) to prevent it from
Hexose-1-6-bisphosphate [6c+2pi] going out of the CELL. [ ACTIVATED PHOSPHORYLATED SUGAR]
TP [3c+pi] TP [3c+pi]
Intermediate [3c] Intermediate [3c]
Pyruvate [3c] Pyruvate[3c]…read more

Slide 5

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Stage 2: Splitting of hexose-1-6-bisphosphate
Glucose
Glucose-6-
phosphate
Fructose-6-
phosphate
Hexose-1-6-bisphosphate Hexose -1-6-bisphosphate SPLITS into triose phosphate
TP TP
Intermediate Intermediate
Pyruvate Pyruvate…read more

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Stage 2 : OXIDATION OF TP ( TP RELEASE H ATOM)
NAD is h atom
Glucose
2 RED acceptor
NAD &
2ATP Glucose-6-
phosphate
Fructose-6-
phosphate Each TP
molecule gives
out a hydrogen
atom (1
Hexose-1-6-bisphosphate electron) This
ATP [S.L.
ATP [S.L. P] attaches onto
P] NAD ( reducing
H ATOM
it) to form
TP TP REDNAD REDUCED
REDNAD H ATOM
Dehydrogenase
NAD
Dehydrogenase
enzymes aid
enzymes aid
Intermediate Intermediate removal of
removal of
hydrogen
hydrogen
Pyruvate Pyruvate…read more

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