Influenza
- Created by: Emilyburkee
- Created on: 01-01-23 12:08
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- influenza
- Virology
- Envolped
- negitive sense
- RNA
- 7/8 segmengts
- Each segment of genome= bound to nucleoprotein in a ribonucleoprotein complex
- pleomorphic
- 4 subtypes = A,B,C and D
- epidemiology
- A = has the largest host range
- A+B are responsible for human infection
- nameing
- A/Sydney/05/97(H3N2)
- A= virus type
- sydney = place isolated
- 05= strain number
- 97 = year isolated
- H3N2= subtype
- Untitled
- clades
- after subtyes it can be grouped into clades and subclades
- A/Sydney/05/97(H3N2)
- virus life cycle
- binding -HA proteins bind to sialic acid ( except HA17+HA18)
- Internalisation
- endosomal, low PH triggers fusion of viral envolope with endosomal membrane
- uncoating
- RNPs are released into host cytosol. RNPs transported to the nucleus where mRNA is transcribed
- Translation
- Viral polymerase subunits and NP proteins move to the nucleus to form RNPs
- Assembly and budding
- HA, NA and M2 proteins trafficked to the cell membrane. RNPs in the nucleus and move to the cytosol then the cell membrane.Virions bud from the cell membrane
- antigenic shift = intermixing of RNA ( combination of antigens) differnet strains infecting same host
- Occurs among influenza viruses of the same genus. Most common in IAV
- Antigenic drift= accumulations of mutation over time
- Influenza A, then B
- Virology
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