Cystic Fibrosis - effects on the digestive system

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  • CYSTIC FIBROSIS -Effect on the digestive system
    • Difficulty maintaining body mass
      • Problems with digestion + absorption of nutrients
      • High basal metabolic rate
      • Poor appetite - require 120-140% of recommendeddaily intake
        • Take food supplements containing digestive enzymes - break down large food molecules
    • Small intestine - breakdown of food molecules + absorption of soluble products into the blood.
    • Gut - glands secrete digestive enzymes in the lumen - act as catalysts to speed up the breakdown of food.
      • Enzymes built into membranes of gut wall.
    • Pancreas - groups of pancreatic cells produce enzymes which help in the breakdown of proteins, carbs and lipids.
      • These enzymes are delivered to the gut in pancreatic juice released through the pancreatic duct.
        • Pancreatic duct blocked by sticky mucus
          • Pancreas - groups of pancreatic cells produce enzymes which help in the breakdown of proteins, carbs and lipids.
            • These enzymes are delivered to the gut in pancreatic juice released through the pancreatic duct.
              • Pancreatic duct blocked by sticky mucus
                • Impairs release of digestive enzymes. Reduces rate of digestion.
                  • Food not fully digested - not all nutrients absorbed. Faeces contains more partially and undigested food - energy is lost.
                • Pancreatic enzymes trapped behind this mucus.
                  • Damage the pancreas. Cysts of hard, damaged tissue form.
          • Impairs release of digestive enzymes. Reduces rate of digestion.
            • Food not fully digested - not all nutrients absorbed. Faeces contains more partially and undigested food - energy is lost.
          • Pancreatic enzymes trapped behind this mucus.
            • Damage the pancreas. Cysts of hard, damaged tissue form.

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