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Chapter 2.4 ­ In depth study of a genetic disease.

Cystic fibrosis is caused when the chlorine transport system of the exocrine glands, including the
mucus-secreting glands of the airways of the lungs, the gut and the reproductive system and the
sweat glands, don't function properly.

Cystic fibrosis transmembrane regulatory…

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Mucus is secreted throughout the gut to protect it from damage by the digestive enzymes.
But if the mucus is thick and sticky, it forms a barrier between the contents of the gut and
the lining of the small intestine, and clogs up the villi reducing the surface area for…

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Cystic Fibrosis blocks the airways and the surface is coated with thick, sticky mucus preventing the
new DNA in the vectors from reaching the epithelial cells.

Prenatal screening ­ Each pregnancy is screened. To see if the fetus has CF you carry out tests on
some fetal cells. These are…

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