To defend the host against microbial infections by complementing the ability of antibodies/phagocytic cells to clear pathogens from an organism by marking foreign bodies for destruction.
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What are its components?
20 plasma proteins, 10 regulators/receptors
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Describe the organisation of the C1q binding protein
18 polypeptides arranged into a bunch of 6 (3 polypeptide) tulips to form a binding site.
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Name the diseases that occur + their symptoms in the absence of... a) C2 b) factor I or H c) C1-INH
Where are the following complement receptors found? a) CR1 b) CR2 c)CR3
a) erythrocytes b) B-cells c) neutrophils
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What does MASP stand for?
Mannose-binding-lectin Associated Serine Protease
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What are antibodies produced against A, B and O antigens known as? What form do they take?
Isohaemagglutins. IgM
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What is Rh disease also known as?
Haemolytic Disease of the Newborn
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What are serious cases referred to as?
erythroblastosis fetalis
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What is an arthus reaction?
When during a type III immune response, platelets accumulate at site of deposition --> vessel bursts causing haemorrhage of skin
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What is serum sickness caused by?
Injection with horse serum to treat bacterial infections: formation of antibodies against foreign horse proteins. these form immune complexes with antigenic proteins -these complexes are dispersed throughout body -small immune complexes deposit in tissue
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Name two symptoms of serum sickness if a) blood vessel walls b) joint spaces are affected by intravenous administration of foreign protein c) alveolar/capillary interface is affected by inhaled protein
a) vasculitis b) arthritis c) farmer's lung
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How long does type IV hypersensitivity take to occur?
1-3 days after contact with antigen
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How many times more of the antigen does it need than antibody-mediated hypersensitivity?
100-1000x the amount
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How long does type IV hypersensitivity take to occur?
1-3 days after contact with antigen
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How many times more of the antigen does it need than antibody-mediated hypersensitivity?
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