The Complement/Hypersensitivity

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What is the function of complement system?
To defend the host against microbial infections by complementing the ability of antibodies/phagocytic cells to clear pathogens from an organism by marking foreign bodies for destruction.
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What are its components?
20 plasma proteins, 10 regulators/receptors
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Describe the organisation of the C1q binding protein
18 polypeptides arranged into a bunch of 6 (3 polypeptide) tulips to form a binding site.
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Name the diseases that occur + their symptoms in the absence of... a) C2 b) factor I or H c) C1-INH
inflamatory disease (butterly rash, hair + appetite loss), secondary c3 deficiency( susceptibility to bacterial infection), Angioedema
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Where are the following complement receptors found? a) CR1 b) CR2 c)CR3
a) erythrocytes b) B-cells c) neutrophils
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What does MASP stand for?
Mannose-binding-lectin Associated Serine Protease
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What are antibodies produced against A, B and O antigens known as? What form do they take?
Isohaemagglutins. IgM
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What is Rh disease also known as?
Haemolytic Disease of the Newborn
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What are serious cases referred to as?
erythroblastosis fetalis
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What is an arthus reaction?
When during a type III immune response, platelets accumulate at site of deposition --> vessel bursts causing haemorrhage of skin
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What is serum sickness caused by?
Injection with horse serum to treat bacterial infections: formation of antibodies against foreign horse proteins. these form immune complexes with antigenic proteins -these complexes are dispersed throughout body -small immune complexes deposit in tissue
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Name two symptoms of serum sickness if a) blood vessel walls b) joint spaces are affected by intravenous administration of foreign protein c) alveolar/capillary interface is affected by inhaled protein
a) vasculitis b) arthritis c) farmer's lung
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How long does type IV hypersensitivity take to occur?
1-3 days after contact with antigen
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How many times more of the antigen does it need than antibody-mediated hypersensitivity?
100-1000x the amount
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How long does type IV hypersensitivity take to occur?
1-3 days after contact with antigen
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How many times more of the antigen does it need than antibody-mediated hypersensitivity?
100-1000x the amount
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Name the 4 types of hypersensitivity
1) IgE mediated 2) antibody-dependent Cytotoxicity 3) Immun-complex mediated 4) delayed-type
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Card 2

Front

What are its components?

Back

20 plasma proteins, 10 regulators/receptors

Card 3

Front

Describe the organisation of the C1q binding protein

Back

Preview of the front of card 3

Card 4

Front

Name the diseases that occur + their symptoms in the absence of... a) C2 b) factor I or H c) C1-INH

Back

Preview of the front of card 4

Card 5

Front

Where are the following complement receptors found? a) CR1 b) CR2 c)CR3

Back

Preview of the front of card 5
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