A chronic inflammatory autoimmune disease characterised by synovial joint inflammation
Majority of patients get joint destruction resulting in loss of movement and stiffness
No cure
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What are some risk factors of RA?
Genetics: HLA-DR 4 (shared epitope)
Lifestyle: overweight, smoking
Trauma
Gender: Women before menopause
Infection: Bacterial and viral DNA has been in synovial membrane
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What drugs are used to treat RA?
Immunotherapy, DMARDs: methotrexate, sulphasalazine, hydoxycholoroquine, leflunomide
NSAIDS and analgesics
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What is methotrexate mechanism of action?
Inhibits dihydrofolate reductase
Tetrahydrofolate is a co factor in the de novo purine synthetic pathway to form DNA
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What is TNF-a?
Tumor necrosis factor is an inflammatory cytokine produced by macrophages during acute inflammation.
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Other cards in this set
Card 2
Front
What are some risk factors of RA?
Back
Genetics: HLA-DR 4 (shared epitope)
Lifestyle: overweight, smoking
Trauma
Gender: Women before menopause
Infection: Bacterial and viral DNA has been in synovial membrane
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