S2W1 Corticosteroids (PD) 0.0 / 5 ? OtherPharmacodynamicsUniversityNone Created by: Tino MurondaCreated on: 25-03-21 13:45 What are corticosteroids? A class of drug that lower inflammation in the body 1 of 7 What does cortisol do? Acts on carboydrate and proteins to decrease uptake and increase catabolism Act via glucocorticoid receptors 2 of 7 What does aldosterone do? Regulates water and electrolyte balance 3 of 7 How is glucocorticoid release regulated? Under the control of the hypothalamus-pituitary-adrenal (HPA) axis Subject to negative feedback contol 4 of 7 What is the mechanism of action of glucocorticoids? Can upregulate transcriptional machinery (TM) that is operating at a low level, or repress the activity of transcription factors (TF) on the TM 5 of 7 How does the mechanism of action of glucocorticoids facilitate the action of anti-inflammatory and immunosupressives? aid in silencing the proinflammatory genes leading to decreased synthesis of cytokines, chemokines, adhesion molecules and inflammatory mediators 6 of 7 What are some clinical manifestations of glucocorticoids? Metabolic syndrome, bone loss, mood shift, cushings syndrome, hyperglycaemia, muscle wasting 7 of 7
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