S2W10 Obesity (FS)

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What are the health risks of obesity?
CVD
Diabetes
Some cancers
Musculoskeletal Diseases
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What is the BMI for obesity?
30 or higher
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What is the fundamental cause of weight gain?
An energy imbalance between calories consumed and calories used up
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What is leptin?
A product of the ob gene, synthesised in adipocytes
It decreases body weight and is a hormone that regulates body weight
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What is the neural pathway for decreased food intake?
Neural pathways in the brain are stimulated by hormones in response to hunger or feeding.
Leptin increases as a result of feeding, it stimulates POMC neurons to release aMSH. This increases energy expenditure and decreases food intake.
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What is the neural pathway for increased food intake?
When leptin levels fall NPY/AGRP neurons are stimulated resulting in the release of peptides which stimulate appetite, increasing food intake and decrease in energy expenditure
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What is ghrelin?
A hormone with opposite effects to leptin, it released from the stomach and levels are high before eating and in periods of hunger. It inhibits those POMC neurons and stimulates NPY/AGRP neurons to increase appetite. Levels fall after eating
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What are some monogenetic causes of obesity linked to?
Leptin receptors
POMC neurons
Melanocortin receptors
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Card 2

Front

What is the BMI for obesity?

Back

30 or higher

Card 3

Front

What is the fundamental cause of weight gain?

Back

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Card 4

Front

What is leptin?

Back

Preview of the front of card 4

Card 5

Front

What is the neural pathway for decreased food intake?

Back

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