S2W1 The effects of age on drug handling (PK)

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What does neonate mean?
0-27 days of life
Corrected age = chronological age - prematurity(40 - gestational age)
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What is an infant?
28 days - 1 year
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What is a child?
1 -18 years
some use 16 as a cut off
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What is chronological age?
Age from birth to current date
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What is gestational age?
Length of pregnancy from first day of mothers last period tobirth date
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What is post-menstrual age?
Gestational age + chronological age
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What are the pharmacokinetic changes in early life?
neonate only 50-60% water
this increases rapidly by 1 years old
neonates only have 10% body fat compared to 25-30% adults, this results in a higher vd for water-soluble drugs in neonates compared with children and adults
low plasma protein conc in neonate
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What is old?
>75 old-old >85
Total body water reduces with age
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Other cards in this set

Card 2

Front

What is an infant?

Back

28 days - 1 year

Card 3

Front

What is a child?

Back

Preview of the front of card 3

Card 4

Front

What is chronological age?

Back

Preview of the front of card 4

Card 5

Front

What is gestational age?

Back

Preview of the front of card 5
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