Pharmocology - other drugs

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  • Created by: Louisa
  • Created on: 05-01-21 17:49
NSAIDs are what
non-steroidal anti inflammatory drugs
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NSAIDS inhibit what ... causing the inhibition of what...
cyclooxygenase - inhibiting prostaglandins
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prostaglandins are realeased where
locally in the tissue in response to chemical or traumatic stimuli
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cox 1
involved in Gi tract and glepes with platelet aggregation and hemostatsis
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Cox 2
pain and inflammation
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cox 3
heart, brain and spinal cord - regulating pain
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selective Cox1 inhibitors drug is
aspirin
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non selective Nsaids
ibruprofen, naproxen, diclofenac
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selective cox 2 inhibitor drug
celeoxib
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low dose is good for
pain relief
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high dose is for
treatment of inflammation
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side effect
gi bleeding, peptic ulcer, renal + hepatic function
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aspirin is given for
pain, fever, inflammation, MI, stroke, thromboembolism
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antipyrexic analgesia includes what drugs
paracetamol
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what cox is also inhibited with paracetamol
COX 3
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what is histamine
a chemical messenger
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wide range of response include what
inflammatory, gastric, secretion and neurotransmitter
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histamine is released from cells in a response of various stimuli
tissue damage, allergic reaction, drug or foreign compounds
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H1 and H2 receptors are targets for... and found where
antihistamines
heart, brain and mast cells
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H3 is related to
CNS conditions e.g. ADHD
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H1 antagonists are given for what syptoms
allergies, cold, nausea and vomiting
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1st generation h1 include drugs
chlorophenamine and promethazine
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have sedative properties because they cross the
blood brain barrier and enter the CNS
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2nd generation h1 antagonists include drugs
loratadine, fexofenadine and certrizine
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they do not
cross bbb, so no cns action, resulting in so sedative properties
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immunosuppressive drugs
autoimmune cond. and organ transplant
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drugs include
corticosteroids, calcineurin inhibitors
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vitamin b12, iron and folic acid is for
anemia
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vit d
cholecalcifrol
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vit k
warfarin antidote
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folic acid
early stages of pregnancy
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paracetamol overdose causes what damage
liver damage
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what is the name of the antidote available
acetylcysteine (within 8 hrs)
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What is hematopiesis
formation of blood
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hematopoietic drugs
involvoled in hematopiesis
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antibiotics were discovered by
alexander fleming
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bactericidal
kills bacteria
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bacteriostatic
stops bacteria from reproducing
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broad spectrum
broad spectra of activity, bacteria doesn't need identifying
but leads to an increase in antibiotic resistance
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narrow spectrum
bacteria needs to be identified, causing less antibiotic resistance
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selective toxicity
target different parts of the cell
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folate interference refers to what
folate is required by human and bacteria, exceot bacteria produced its own foalte, antibiotics interfere with this process
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cell wall synthysis inhibitor inhibits the synthesis of what
peptidoglycan, inhibiting the bacterial cell wall synthesis
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how does this cause the cell wall to break
cells swell, rupture, and cause death of bacterium
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penicillin has a high
resistance due to heavy use
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benzylpenicillin is used by paras for what
in mengingingitis
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protein synthesis interface is a target for
bacterial ribosomes, and inhibits bacterial protein synthesis
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Inhibition for bacterial DNA
during DNA transcription of bacterial DNA what is used that animal cells don't use
DNA gyrase
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antibiotics affect this process by inhibiting
DNA gyrase .. .therefore DNA function
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when should antibiotics be prescribed
bacterial infections, infection is unlikely to clear up, prolonged infection, risk of serious complications, highly contagious
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define antibiotic resistance
ability of bacteria to resist tothe effects of an antibiotic
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why is antibiotic resistance occuring
overuse of antibiotics, inappropriate use, extensive use
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what can we do to help stop antibiotic resistance
prescribe only when needed, ensure good infection control, and finish course of antibiotics
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Antineoplastic drugs target
DNA
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neoplasm is what
the abnormal proliferation of cells, leading to an abnormal mass of tissue growth
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antineoplastic drugs do what
interrupt the development and growth and spread of abnormal cells
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alkylying agents damage the ... preventing
DNA, cell preproduction
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antimetabolites interfere with
with DNA and RNA growth
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DNa intercalating drugs insert themselves into
DNA, prevent division
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cytotoxic agents do what
no-specifically inhibit DNA replication
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targeted anticancer drugs inhibit
specific proteins involved in tumour growth
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chemo drugs damage what
everything, including good cells
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hormones are used in what
drug therapy
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what hormone drug therapies are there
corticosteroids, hormonal contraceptives, anticancer, insulin, thyroid drugs, growth hormone
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what is tamoxifen
anti oesteogen for breast cancer
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Other cards in this set

Card 2

Front

NSAIDS inhibit what ... causing the inhibition of what...

Back

cyclooxygenase - inhibiting prostaglandins

Card 3

Front

prostaglandins are realeased where

Back

Preview of the front of card 3

Card 4

Front

cox 1

Back

Preview of the front of card 4

Card 5

Front

Cox 2

Back

Preview of the front of card 5
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