S1W8 Administering drugs by the topical route - PK

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What are some examples of topically administered routes?
Sublingual
Transdermal patch
Inhalation
Rectal
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What is topical administration?
Drug applied to a localised area of the body surface to minimise systemic side effects
Drug applied to a body surface to provide an alternative and convenient route into blood
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Why do some people have the topical route instead of the oral route?
In the oral route drugs are subject to first pass metbolism in the liver
Some drugs need faster onset
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When is topical administration used?
Skin
Eye
Nose
Lung
Vagina
Rectum
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What are some topical formulations?
Creams
Ointments
Gels
Transdermal patch
Solutions
Powders
Foams
Enemas
Suppositories
Pessaries
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What route does a drug use if it is lipophilic?
Utilises the intracellular route
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What route does a drug use if it is hydrophilic?
Utilises the intercellular route
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Card 2

Front

What is topical administration?

Back

Drug applied to a localised area of the body surface to minimise systemic side effects
Drug applied to a body surface to provide an alternative and convenient route into blood

Card 3

Front

Why do some people have the topical route instead of the oral route?

Back

Preview of the front of card 3

Card 4

Front

When is topical administration used?

Back

Preview of the front of card 4

Card 5

Front

What are some topical formulations?

Back

Preview of the front of card 5
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