Solid dosage form: Semi solids
- Created by: Creny
- Created on: 30-03-15 14:07
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- SOLID DOSAGE FORM: TOPICAL
- Skin
- complex organ
- 4 distinct layers
- stratum corneum (non viable epidermis)
- viable dermis
- viable epidermis
- granular layer, spinous layer and basal layer
- Hypodermis- subcutaneous connective tissue
- surface maintained
- 4 distinct layers
- 10% of body mass
- 2 functions
- homeostasis
- barrier
- appendages
- eccrine sweat glands
- (not a route for administration)
- body temp homeostasis and emosional responce
- apocrine sweat glands
- emulsifier of sweat
- eccrine sweat glands
- complex organ
- Drug transport
- 3 main routes
- shunt routes- partitioning into sweat & sebum
- Intercellular route- partitioning into lipid
- Intracellular route- partitioning into corneycyte
- partition & diffusion process
- partition each way into lipid and aqueous domain
- diffusion through aqueous and lipid in same direction
- equation to predict rate of drug transport into skin
- topical & transdermal preparations
- 1- select suitable drug molecules
- 2- appropriate release of the drug
- 3- achieving highest flux
- 4- alcohol can help
- 5- occlusion increases delivery of most drugs
- 3 main routes
- 5 target regions
- surface treatment
- stratum corneum
- skin appendages
- viable epidermis - dermis
- systemic treatment
- identifying candidate drugs for transdermal delivery
- physiochemical nature of drug
- potency
- timescale of exposure
- site and condition of skin
- formulation e.g. penetration enhancers
- skin hydration
- advantages of transdermal
- avoids first pass
- consistent drug input rate
- stop dosing by removing patch
- Skin
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