Solid dosage form: Semi solids

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  • Created by: Creny
  • Created on: 30-03-15 14:07
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  • SOLID DOSAGE FORM: TOPICAL
    • Skin
      • complex organ
        • 4 distinct layers
          • stratum corneum (non viable epidermis)
          • viable dermis
          • viable epidermis
            • granular layer, spinous layer and basal layer
          • Hypodermis- subcutaneous connective tissue
          • surface maintained
      • 10% of body mass
      • 2 functions
        • homeostasis
        • barrier
      • appendages
        • eccrine sweat glands
          • (not a route for administration)
          • body temp homeostasis and emosional responce
        • apocrine sweat glands
          • emulsifier of sweat
    • Drug transport
      • 3 main routes
        • shunt routes- partitioning into sweat & sebum
        • Intercellular route- partitioning into lipid
        • Intracellular route- partitioning into corneycyte
      • partition & diffusion process
        • partition each way into lipid and aqueous domain
        • diffusion through aqueous and lipid in same direction
        • equation to predict rate of drug transport into skin
      • topical & transdermal preparations
        • 1- select suitable drug molecules
        • 2- appropriate release of the drug
        • 3- achieving highest flux
        • 4- alcohol can help
        • 5- occlusion increases delivery of most drugs
    • 5 target regions
      • surface treatment
      • stratum corneum
      • skin appendages
      • viable epidermis - dermis
      • systemic treatment
    • identifying candidate drugs for transdermal delivery
      • physiochemical nature of drug
      • potency
      • timescale of exposure
      • site and condition of skin
      • formulation e.g. penetration enhancers
      • skin hydration
    • advantages of transdermal
      • avoids first pass
      • consistent drug input rate
      • stop dosing by removing patch

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