Medications - Paracetamol

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Paracetamol:
Route? Dose Range?
R = Oral, Suppository, Intravenous
D.R = 0.5-1g, 4-6 hours
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Paracetamol:
Indications? Cautions?
I = mild-moderate pain, pyrexia
C = <50kg body weight, chronic alcohol consumption, chronic hydration
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Paracetamol:
Side effects? Toxicity?
S.E = thrombocytopenia, hypersensitivity, rash, bronchospasm, tachycardia
T = liver and renal damage
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Paracetamol:
Mechanism of Action
M.o.A = inhibits prostaglandin synthesis, reduces effort of heat regulating centres in brain
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Paracetamol:
Absorption? Distribution?
A = 88% oral bioavailability, peak plasma concentration 90 mins after digestion. Rectal 1/2 plasma conc. of = oral dose, 3 hours post administration
D = 0.9L/kg, widely through body tissues except fat. 10-20% binds to RBCs
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Paracetamol:
Metabolism? Elimination?
M = liver via 1st order kinetics. conjugation with glucuronide + sulfate. oxidation via cp450 enzyme pathway -> reactive metabolite
E = via urine, <5% free/unchanged, 90% removed in 24 hours
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Other cards in this set

Card 2

Front

Paracetamol:
Indications? Cautions?

Back

I = mild-moderate pain, pyrexia
C = <50kg body weight, chronic alcohol consumption, chronic hydration

Card 3

Front

Paracetamol:
Side effects? Toxicity?

Back

Preview of the front of card 3

Card 4

Front

Paracetamol:
Mechanism of Action

Back

Preview of the front of card 4

Card 5

Front

Paracetamol:
Absorption? Distribution?

Back

Preview of the front of card 5
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