oral- solutions 0.0 / 5 ? Biotechnologyoral solutionsUniversityNone Created by: anna888Created on: 28-02-23 17:29 advantages of oral solutions fast absorbtion,uniform dose, easy to swallow and manufacture 1 of 9 disadvantages oral solutions expensive manufacturing transport and storage, bad taste, drugs poor water solubility, less stable 2 of 9 excpients in solution viscoisty enhances-improve pouring eg glycerine. preservatives-prevent microbial growth eg benzoic acid. sweeters/flavourins-palatibility eg sucrose. antioxidants-increase stability eg ascorbic acid 3 of 9 factors effecting solution degradation pH, temp, uv light, oxygen 4 of 9 prolonging stability methods pH buffers eg citrate or phosphate. antioxidants, containers that lower uv light entering 5 of 9 4 methods of increasing solubility pH modification, complexation, co solvents, surfactants 6 of 9 explain complexation using cyclodextrins. ring sugars with hydrophobic core and hydrophillic outer layer. drug enters middle and made more soluble 7 of 9 explain cosolvents other water miscible solvents used to increase solubility. ethanol, gycerol, propylene glycol. based on like dissolves like principal 8 of 9 explain surfactants hydrophillic head, hydrophobic tail. above cmc forms miscelle around drug, makes it more soluble. 9 of 9
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