modulators of neuronal excitability

?
which ion channel is not considered for this regard?
Voltage-gated cannolin ion channels
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a Modulators of voltage-gated (VG) Na channel, includes what drug?
PHENYTOIN
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what Na+ channels does phenytoin work on?
INACTIVATED
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NAME ANOTHER Modulators of VG Na channel
CARBAMAZEPINE
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CARBAMAZEPINE results in what change in neuronal excitability?
decrease
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select the example of a modulator of a voltage gated calcium channel
ETHOSUXIMIDE
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what type of calcium channels does ETHOSUXIMIDE block?
T-type
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what type of voltage-activated channels does ethosuximide hit?
low
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ethosuximide is activated by what depolarisations of the plasma membrane
small
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small depolarisations of the plasma membrane, leads to membrane what and opening of voltage-gated ion channels
depolarisation
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which drug would be used for high voltage activated calcium channels
GABAPENTIN
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what subunit does GABAPENTIN modulate?
a1
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what subunit does GABAPENTIN bind to?
α2δ
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what do we want to keep open to cause a decrease in our membrane potential?
potassium channels
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name a modulators of VG Potassium channels
RETIGABINE
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Kv are opened in response to depolarisation (inside of the cell becoming more positive) of the membrane during an action potential, This results in K+ ions (positive charge) leaving the cell. This loss of positive charge results in the inside of the cell
decreased
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what 5HT modulator is an auto-receptor? inhibitory found on serotonin cells
5HT1
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NAME 5HT1 MODULATORS. SELECT WRONG ONE
ONDANSETRON
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WHAT NERVE ENDINGS DOES SUMATRIPTAN ACT ON
Trigeminal
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what Decrease the release of pain and inflammatory mediators from trigeminal nerve endings
2) Cause vasoconstriction of intracranial arteries, counteracting vasodilation associated with headaches.
Triptans
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which 5HT receptor is ionotropic and excitatory
5HT3
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name a 5HT3 modulator
ONDANSETRON
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5HT3 is an ionotropic receptor.
5HT3 receptor activation allows for the flow of cations into the cell. 5HT3 receptor activation results in what
depolarisation
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where are 5HT3 receptors expressed: select incorrect answer
Hypothalamus inhibiting the activity of afferents connected to neurons in the CTZ.
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name a dopamine 2 (D2) receptor acting on vomiting centre
HALOPERIDOL
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name a mixed modulator working at D2 receptors and 5HT3 receptors
METOCLOPRAMIDE
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which drug is a mixed 5-HT and Dopamine receptor modulator, that works against schizophrenia
RISPERIDONE
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Binds SELECTIVELY to the serotonin transporter (SERT) and inhibits neuronal reuptake of serotonin away from the synaptic cleft. Called a selective serotonin reuptake inhibitor (SSRI).
SERTRALINE
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Card 2

Front

a Modulators of voltage-gated (VG) Na channel, includes what drug?

Back

PHENYTOIN

Card 3

Front

what Na+ channels does phenytoin work on?

Back

Preview of the front of card 3

Card 4

Front

NAME ANOTHER Modulators of VG Na channel

Back

Preview of the front of card 4

Card 5

Front

CARBAMAZEPINE results in what change in neuronal excitability?

Back

Preview of the front of card 5
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