M.o.A = inhibits Na-K ATPase enzyme -> increases myocardial contraction force by increasing calcium in myocardial cells. Decreases heart rate by stimulating parasympthatic nervous system
4 of 6
Digoxin:
Absorption? Distribution?
A = 50-90% oral bioavailability. 70-80% in 1st part of small bowel. peak conc. up to 1 hour post administration, food slows rate.
D = vol = 475-500L, widely across skeletal muscle, heart + kidneys. crosses blood brain barrier + placenta, 25% protein bound
5 of 6
Digoxin:
Metabolism? Elimination?
M = 13% into urinary metabolites. hydroxylation, oxidation + conjugation forms glucuronidated + sulfated conjugates
E = 50-70% via urine, 25-28% kidneys, biliary excretion is minimal.
6 of 6
Other cards in this set
Card 2
Front
Digoxin:
Indications? Cautions?
Back
I = Atrial Fibrillation, Flutter, Heart failure in sinus rhythm
C = Constrictive pericarditis, myocarditis, hypertrophic cardiomyopathy
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