M.o.A = conversion to aciclovir triphosphate, inhibiting viral DNA polymerase causing DNA chain termination
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Aciclovir:
Absorption? Distribution?
A = 10-20% oral bioavailability, decreases with increased doses. <0.02-9.4% topical. buccal + opthalmic minimal. food doesn't affect bioavailability
D = 0.6L/kg. 9-33% plasma protein bound
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Aciclovir:
Metabolism? Elimination?
M = <15% oxidised to 9-carboxymethoxymethylguanine. 1% 8-hydroxylated to 8-hydroxy-aciclovir
E = 90-92% via glomerular filtration + tubular secretion in urine + unchanged. <2% faeces. <0.1% CO2 expiration
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Other cards in this set
Card 2
Front
Aciclovir:
Indications? Cautions?
Back
I = herpes simplex, herpes zoster, varicella zoster
C = renal failure, hypersensitivity, immunocompromised patients
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