2. All B cell begin my making IgM. Memory cells produce IgG, IgA or IgE with same specificity from IgM. So the same VH, VL domain. Different type of antibody in secondary response
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3. What is TCR and its function?
3. Structure on t cell surface that recognises antigen. Binds to antigenic peptide associated with MHC
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4. What are alpha and beta chains linked by?
4. Disulphide bond
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5. What happens after T H binds to antigen?
5. Cells secrete growth factors (cytokines) which control immune response
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6. How do cytokines coordinate the response?
6. Th cells produce interferon gamma. APC release interleukin 1. Other t cells which have recognised Ag make iL 2. T H cells which have bound Ag make other growth factors
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7. What happens after Tc gets activated?
7. Release perforins which form pores in target cell. Release other damaging enzymes. Release cytokines like TNF alpha and beta, IFN gamma TNF. Triggers apoptosis helped by IFN gamma
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what are cells with same specificity called
clones
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what antigen receptor is found on B and T cells?
B cell: cell surface antibody T cell: TCR
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what is the antigen receptor on B cells?
the antibody that the B. cell is. programmed to make
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what is the sequence of antibody diversity
transcription, splicing out, translation
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what do T cell independent antigens produce
IgM antibodies in small amounts
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what do TCR bind to?
antigenic peptide associated with MHC
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Vaplha and Vbeta have.......... or........ responsible for detecting antigenic peptide in combination with MHC
hypervariable loops or CDRs
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what proteins are associated with helper T cells TCR and cytotoxic T cells TCR
helper= CD8+CD3. Cytotoxic= CD8+CD3
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When CD4+T cell what is secreted
cytokines that favour macrophage activation and cell mediated responses. or cytokines that stimulate B cells to produce antibodies
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Other cards in this set
Card 2
Front
2. What is class switching?
Back
2. All B cell begin my making IgM. Memory cells produce IgG, IgA or IgE with same specificity from IgM. So the same VH, VL domain. Different type of antibody in secondary response
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