IMMs ILA 1 Sickle Cell Disease 0.0 / 5 ? MedicineMedicineUniversityNone Created by: AnneBoleyn1501Created on: 14-10-22 15:59 Sickle cell disease can be treated with hydroxyurea because it….. Increases the synthesis of HbF (Foetal Hb) 1 of 18 Specific amino acids bind to Transfer RNA 2 of 18 Alpha helixes and beta sheets are examples of protein… 2ry structure 3 of 18 A protein with a number of sub units held together by cross links has this type of structure 4ry structure 4 of 18 This enzyme causes the double helix to unzip Helicase 5 of 18 In Sickle Cell disease the HbS structural change causes sickling by… Binding to the cytoskeleton 6 of 18 Sickle cell anaemia (HbS) is caused by An autosomal recessive inherited condition substituting an amino acid in the beta globin chain 7 of 18 In Sickle Cell disease an acute pain crisis is typically caused by capillary occlusion in the … Bone 8 of 18 In Sickle Cell disease hypoxia causes the abnormal HbS to… Polymerise 9 of 18 This enzyme unwinds supercoiled DNA Topoisomerase 10 of 18 The process in which mRNA is used to specify the amino acids required for protein formation is known as Translation 11 of 18 In Sickle Cell disease capillary occlusion is now thought to occur by…. Endothelial damage causing multicellular (platelets, white cells) aggregates which occlude the capillary 12 of 18 When there's a lack of blood flow to a certain area leading to a lack of oxygen Ischemia 13 of 18 unprogrammed cell death necrosis 14 of 18 Lifespan of a normal cell 120 days 15 of 18 Why does stress make you more likely to have a sickle cell crisis? Vasoconstriction 16 of 18 If a patient presents in A+E with a sickle cell crisis, what are the first 3 things to do. Oxygen, morphine, fluids 17 of 18 Occlusion (haem) meaning Blockage of blood vessel 18 of 18
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