1. signal binds, conformational change in receptor causing dimerizaton and activation 2.guanylyl cycase domain activated on receptor so cGMP is prouduced
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where is receptor guanylyl cyclase found
relaxation of smooth muscle and dilates blood vessles
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main function/structure of serine/theronine (ser/thr) kinase
has type i and type ii sections- ternary complex. ser/thr domains phosphorilate protiens
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mechanism of action ser/thr kinase
1. ligand binds to type ii 2.dimerization of type i and type ii 3.type ii phosphorilates type i activating ser/thr domain on type i which phorphilate protiens
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wher is ser/thr kinase receptors found
relates to cell proliferation (cclin CDK activation at checkpoints)
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