CYP450

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1. CYP2E1

  • ethanol metabolism- autoinduction
  • found outside the liver and induced by some of its substrates + involved in the activation of PAHs
  • metabolises pro-drugs
  • activates aryl amine compounds to carcinogens and metabolises caffeine
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Other questions in this quiz

2. Which CYP isoform is subject to genetic polymorphism (low activity due to amino-acid substitutions)

  • CYP2C9
  • CYP2D6
  • CYP3A4
  • CYP2C19

3. Which CYP can performs aromatic or aliphatic hydroxylation:

  • CYP3A4
  • CYP2C9
  • CYP2C19
  • CYP2D6

4. CYP2C9 substrates include:

  • omeprazole, clopidogrel
  • debrisoquine, amitriptyline, codeine
  • ibuprofen, s-warfarin, tienllic acid
  • verapamil, lidocaine, cyclosporin

5. 5-10% of the population lack the enzyme due to mutations?

  • CYP2C19
  • CYP3A4
  • CYP2D6
  • CYP2C9
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