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6. Which CYP normally performs N-dealkylation?

  • CYP3A4
  • CYP2C9
  • CYP2C19
  • CYP2D6

7. CYP2C19 substrates include:

  • debrisoquine, amitriptyline, codeine
  • verapamil, lidocaine, cyclosporin
  • omeprazole, clopidogrel
  • ibuprofen, s-warfarin, tienllic acid

8. CYP2D6 substrates have?

  • hydrophobic interactions
  • hydrophilic with sulphur centres
  • basic nitrogen, ionised at physiological pH, hydrophobic region
  • strong hydrogen bond forming potential or ion pair formation

9. CYP4:

  • fatty acid oxidation
  • retinoid acid oxidation
  • steroid biosynthesis (oestrogen)
  • all drug metabolism

10. Which CYP can performs aromatic or aliphatic hydroxylation:

  • CYP3A4
  • CYP2C9
  • CYP2C19
  • CYP2D6

11. Most drugs are metabolised by which 3 CYP45Os?

  • CYP2D6, CYP2C9, CYP3A4
  • CYP1A1, CYP2D6, CYP2E1
  • CYP2D6, CYP3A4, CYP2C19
  • CYP2C9, CYP2E1, CYP1A1

12. CYP1A2

  • activates aryl amine compounds to carcinogens and metabolises caffeine
  • found outside the liver and induced by some of its substrates + involved in the activation of PAHs
  • metabolises pro-drugs
  • ethanol metabolism- autoinduction

13. CYP2E1

  • ethanol metabolism- autoinduction
  • found outside the liver and induced by some of its substrates + involved in the activation of PAHs
  • metabolises pro-drugs
  • activates aryl amine compounds to carcinogens and metabolises caffeine

14. CYP1A1

  • metabolises pro-drugs
  • found outside the liver and induced by some of its substrates + involved in the activation of PAHs
  • activates aryl amine compounds to carcinogens and metabolises caffeine
  • ethanol metabolism- autoinduction

15. CYP26:

  • retinoid acid oxidation
  • fatty acid oxidation
  • steroid biosynthesis (oestrogen)
  • all drug metabolism

16. CYP2D6 substrates include:

  • debrisoquine, amitriptyline, codeine
  • omeprazole, clopidogrel
  • ibuprofen, s-warfarin, tienllic acid
  • verapamil, lidocaine, cyclosporin

17. Which CYP isoform is not induceable?

  • CYP2C19
  • CYP2D6
  • CYP3A4
  • CYP2C9

18. CYP2C9 substrates include:

  • omeprazole, clopidogrel
  • ibuprofen, s-warfarin, tienllic acid
  • verapamil, lidocaine, cyclosporin
  • debrisoquine, amitriptyline, codeine

19. Which CYP normally performs aromatic hydroxylation:

  • CYP3A4
  • CYP2D6
  • CYP2C9
  • CYP2C19

20. CYP3A4 substrates include:

  • debrisoquine, amitriptyline, codeine
  • ibuprofen, s-warfarin, tienllic acid
  • verapamil, lidocaine, cyclosporin
  • omeprazole, clopidogrel