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6. Which CYP normally performs N-dealkylation?
- CYP3A4
- CYP2C9
- CYP2C19
- CYP2D6
7. CYP2C19 substrates include:
- debrisoquine, amitriptyline, codeine
- verapamil, lidocaine, cyclosporin
- omeprazole, clopidogrel
- ibuprofen, s-warfarin, tienllic acid
8. CYP2D6 substrates have?
- hydrophobic interactions
- hydrophilic with sulphur centres
- basic nitrogen, ionised at physiological pH, hydrophobic region
- strong hydrogen bond forming potential or ion pair formation
9. CYP4:
- fatty acid oxidation
- retinoid acid oxidation
- steroid biosynthesis (oestrogen)
- all drug metabolism
10. Which CYP can performs aromatic or aliphatic hydroxylation:
- CYP3A4
- CYP2C9
- CYP2C19
- CYP2D6
11. Most drugs are metabolised by which 3 CYP45Os?
- CYP2D6, CYP2C9, CYP3A4
- CYP1A1, CYP2D6, CYP2E1
- CYP2D6, CYP3A4, CYP2C19
- CYP2C9, CYP2E1, CYP1A1
12. CYP1A2
- activates aryl amine compounds to carcinogens and metabolises caffeine
- found outside the liver and induced by some of its substrates + involved in the activation of PAHs
- metabolises pro-drugs
- ethanol metabolism- autoinduction
13. CYP2E1
- ethanol metabolism- autoinduction
- found outside the liver and induced by some of its substrates + involved in the activation of PAHs
- metabolises pro-drugs
- activates aryl amine compounds to carcinogens and metabolises caffeine
14. CYP1A1
- metabolises pro-drugs
- found outside the liver and induced by some of its substrates + involved in the activation of PAHs
- activates aryl amine compounds to carcinogens and metabolises caffeine
- ethanol metabolism- autoinduction
15. CYP26:
- retinoid acid oxidation
- fatty acid oxidation
- steroid biosynthesis (oestrogen)
- all drug metabolism
16. CYP2D6 substrates include:
- debrisoquine, amitriptyline, codeine
- omeprazole, clopidogrel
- ibuprofen, s-warfarin, tienllic acid
- verapamil, lidocaine, cyclosporin
17. Which CYP isoform is not induceable?
- CYP2C19
- CYP2D6
- CYP3A4
- CYP2C9
18. CYP2C9 substrates include:
- omeprazole, clopidogrel
- ibuprofen, s-warfarin, tienllic acid
- verapamil, lidocaine, cyclosporin
- debrisoquine, amitriptyline, codeine
19. Which CYP normally performs aromatic hydroxylation:
- CYP3A4
- CYP2D6
- CYP2C9
- CYP2C19
20. CYP3A4 substrates include:
- debrisoquine, amitriptyline, codeine
- ibuprofen, s-warfarin, tienllic acid
- verapamil, lidocaine, cyclosporin
- omeprazole, clopidogrel